Table 6.
Author | Site | Study design | Subjects | Study group | Control group | Intake | Outcome |
---|---|---|---|---|---|---|---|
Prentice (Prentice et al. 1987) | Gambia | Historical control | All pregnant women in catchments area | Fortified biscuits and tea | Un‐supplemented | Daily intake about 671 kcal | Significant improvement in birthweight (3010 g vs. 2810 g) in hungry season; no effect in dry season (2972 g vs. 2959 g). |
Ceesay (Ceesay et al. 1997) | Gambia | Cluster‐randomization | Pregnant women from 20 weeks of gestation | Biscuits containing 1015 kcal energy, 22 g protein and 56 g fat. | Un‐supplemented | The maximum intake was two biscuits | Significant increase in birthweight by 201 g in hungry season, but not in harvest season; head circumference in 3.1 mm; reducing odds of stillbirth and all death by 53% and 46%, respectively. |
Huybregts (Huybregts et al. 2009a) | Burkina Faso | RCT | Pregnant women starting from first trimester and some second trimester | LNS fortified with 1 RNI MMN as UNIMMAP | UNIMMAP | 72 g LNS (372 kcal, 14.7 g protein, 27.6 g fat, | No significant difference in birthweight; |
Significantly greater birth length (4.6 mm longer in LNS group) and placental weight (15.6 g heavier) in LNS group. |
LNS, Lipid‐based nutrient supplement; MMN, multiple micronutrient; RCT, randomized controlled trial; RNI, recommended nutrient intake; UNIMMAP, United Nations International Multiple Micronutrient Preparation.