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Table 3.

Adjusted hazard ratio* for stillbirth at ≥28 weeks’ gestation by haemoglobin status at <28 weeks’ gestation: National Maternal and Infant Health Survey 1988, United States (Sanderson et al., 1991)

Timimng of haemoglobin measurement Haemoglobin status
Any anaemia Mild anaemia Moderate or severe anaemia Normal haemoglobin High haemoglobin
Total deliveries HR 95%CI Totaldeliveries HR 95%CI Totaldeliveries HR 95%CI Totaldeliveries HR 95%CI Totaldeliveries HR 95% CI
Black women
<28 weeks 250 1.05 0.68, 1.61 199 1.09 0.68, 1.74 51 0.86 0.32, 2.34 1832 1.00 Ref  48 2.02 0.96, 4.23
<13 weeks 106 0.99 0.16, 2.12  56 1.07 0.50, 2.31 16  696 1.00 Ref  18 3.67 0.92, 14.6
13–27 weeks 144 1.12 0.65, 1.92 143 1.11 0.61, 2.04 35 1.14 0.41, 3.17 1136 1.00 Ref  30 2.69 0.69, 10.5
Non‐black women
<28 weeks  72 0.80 0.41, 1.56  60 0.65 0.31, 1.34 12 4.41 1.02, 19.0 3158 1.00 Ref 214 0.95 0.63, 1.43
<13 weeks  31 0.67 0.25, 1.77  26 0.49 0.16, 1.54  5 2.87 0.33, 25.2  994 1.00 Ref 109 0.70 0.39, 1.25
13–27 weeks  41 1.09 0.46, 2.59  34 0.90 0.35, 2.27  7 9.40 1.50, 59.0 2164 1.00 Ref 105 1.62 0.72, 3.65
*

Hazard ratios were adjusted for maternal age, parity, marital status, maternal education, cocaine use during pregnancy, pre‐pregnancy body mass index, prenatal iron supplementation, and iron/multivitamin use during pregnancy, and pre‐eclampsia/eclampsia.

Maternal haemoglobin concentrations during the first and second trimesters were classified as anaemia (haemoglobin <11.0 g dL−1 and < 10.5 g dL−1, respectively), mild anaemia (10.0 to <11.0 g dL−1 and 9.5 to <10.5 g dL−1), moderate anaemia (9.0 to <10.0 g dL−1 and 8.5 to < 9.5 g dL−1) and high haemoglobin (≥14.6 g dL−1 in either trimester). Normal haemoglobin includes women with neither anaemia nor high haemoglobin.

Number of stillbirths was too few for meaningful analysis.

HR, hazard ratios; CI, confidence intervals; Ref, reference.