Table 3.
Adjusted hazard ratio* for stillbirth at ≥28 weeks’ gestation by haemoglobin status at <28 weeks’ gestation: National Maternal and Infant Health Survey 1988, United States (Sanderson et al., 1991)
Timimng of haemoglobin measurement | Haemoglobin status† | ||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Any anaemia | Mild anaemia | Moderate or severe anaemia | Normal haemoglobin | High haemoglobin | |||||||||||
Total deliveries† | HR | 95%CI | Totaldeliveries† | HR | 95%CI | Totaldeliveries† | HR | 95%CI | Totaldeliveries† | HR | 95%CI | Totaldeliveries† | HR | 95% CI | |
Black women | |||||||||||||||
<28 weeks | 250 | 1.05 | 0.68, 1.61 | 199 | 1.09 | 0.68, 1.74 | 51 | 0.86 | 0.32, 2.34 | 1832 | 1.00 | Ref | 48 | 2.02 | 0.96, 4.23 |
<13 weeks | 106 | 0.99 | 0.16, 2.12 | 56 | 1.07 | 0.50, 2.31 | 16 | ‡ | 696 | 1.00 | Ref | 18 | 3.67 | 0.92, 14.6 | |
13–27 weeks | 144 | 1.12 | 0.65, 1.92 | 143 | 1.11 | 0.61, 2.04 | 35 | 1.14 | 0.41, 3.17 | 1136 | 1.00 | Ref | 30 | 2.69 | 0.69, 10.5 |
Non‐black women | |||||||||||||||
<28 weeks | 72 | 0.80 | 0.41, 1.56 | 60 | 0.65 | 0.31, 1.34 | 12 | 4.41 | 1.02, 19.0 | 3158 | 1.00 | Ref | 214 | 0.95 | 0.63, 1.43 |
<13 weeks | 31 | 0.67 | 0.25, 1.77 | 26 | 0.49 | 0.16, 1.54 | 5 | 2.87 | 0.33, 25.2 | 994 | 1.00 | Ref | 109 | 0.70 | 0.39, 1.25 |
13–27 weeks | 41 | 1.09 | 0.46, 2.59 | 34 | 0.90 | 0.35, 2.27 | 7 | 9.40 | 1.50, 59.0 | 2164 | 1.00 | Ref | 105 | 1.62 | 0.72, 3.65 |
Hazard ratios were adjusted for maternal age, parity, marital status, maternal education, cocaine use during pregnancy, pre‐pregnancy body mass index, prenatal iron supplementation, and iron/multivitamin use during pregnancy, and pre‐eclampsia/eclampsia.
Maternal haemoglobin concentrations during the first and second trimesters were classified as anaemia (haemoglobin <11.0 g dL−1 and < 10.5 g dL−1, respectively), mild anaemia (10.0 to <11.0 g dL−1 and 9.5 to <10.5 g dL−1), moderate anaemia (9.0 to <10.0 g dL−1 and 8.5 to < 9.5 g dL−1) and high haemoglobin (≥14.6 g dL−1 in either trimester). Normal haemoglobin includes women with neither anaemia nor high haemoglobin.
Number of stillbirths was too few for meaningful analysis.
HR, hazard ratios; CI, confidence intervals; Ref, reference.