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. 2019 Jun 20;90(11):1244–1250. doi: 10.1136/jnnp-2018-320071

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Distribution of scores of the primary outcome (Clinical Global Impression-Improvement scale). The thick black line indicates the cut-off point of improvement (score 1, 2 or 3) vs no change or worsening (score 4, 5, 6 and 7). No significant difference was found between the two treatment arms (BoNT vs placebo; proportional difference of 0.075 (95% CI −0.189 to 0.327; p=0.77)). BoNT, botulinum neurotoxin.