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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Hypertension. 2019 Mar;73(3):514–521. doi: 10.1161/HYPERTENSIONAHA.118.11782

Figure 1.

Figure 1.

Isolated aortic segments from normotensive rats incubated with Toll-like receptor (TLR)9 agonist ODN2395 were more sensitive to thromboxane A2 mimetic U46619. Concentration-response curves to U46619 after incubation with vehicle or ODN2395 for (A) 12 (Emax, vehicle: 141±8 vs. ODN2395: 184±12) or (B) 16 hours (Emax, vehicle: 114±5 vs. ODN2395: 161±8). Concentration-response curves to U46619 in aorta from (C) male (Emax, vehicle: 139±7 vs. ODN2395: 190±9) and (D) female (Emax, vehicle: 154±7 vs. ODN2395: 216±12) rats after 12 hours incubation with vehicle or ODN2395. n=3–6. Non-linear regression analysis: *p<0.05 vs. vehicle.