Table 1.
Acute CNO-mediated hM3Dq DREADD activation of hippocampal excitatory neurons does not alter intrinsic membrane properties
| RMP (mV) | Input resistance (MΩ) | AP threshold (mV) | τ (ms) | Sag (mV) | Sag (%) | Accomodation index | |
|---|---|---|---|---|---|---|---|
| Pre-CNO | -61.31 ± 0.62 | 194.9 ± 10.95 | -53.61 ± 0.59 | 26.15 ± 1.57 | -5.67 ± 0.61 | 6.39 ± 0.61 | 0.45 ± 0.04 |
| 30 min Post-CNO (1 μM) | -59.24 ± 1.52 | 173.7 ± 17.47 | -56.04 ± 2.11 | 23.11 ± 1.66 | -4.84 ± 0.85 | 5.82 ± 0.84 | 0.36 ± 0.09 |
| 30 min Post-CNO (20 μM) | -62.30 ± 1.31 | 201.8 ± 13.21 | -53.39 ± 1.22 | 27.05 ± 3.03 | -4.71 ± 0.72 | 5.30 ± 0.74 | 0.47 ± 0.08 |
AP threshold: action potential threshold; τ: membrane time constant.