Table 4. Functional classification of the upregulated genes according to the pathways they influence and control.
| Pathway | No of genes | Percentage | ||
|---|---|---|---|---|
| 1 | Gonadotropin-releasing hormone receptor pathway (P06664) | 11 | CTNNB1, IGF1R, ITGB1, NR3C1, PIK3R1, STAT3, VCL, BMPR2, RAC1 | 16.7% |
| 2 | Integrin signaling pathway (P00034)* | 7 | ARPC2, PIK3C2A, ITGB1, PIK3R1, VCL, RAC1, | 10.6% |
| 3 | Inflammation mediated by chemokine and cytokine signaling pathway (P00031)* | 6 | ARPC2, ITGB1, MYH9, MYH10, STAT3, RAC 1 | 9.1% |
| 4 | EGF receptor signaling pathway (P00018)* | 6 | YWHAH, PIK3C2A, YWHAQ, GAB1, STAT3, RAC1 | 9.1% |
| 5 | CCKR signaling map (P06959)* | 6 | CTNNB1, PIK3C2A, JAK1, PIK3R1, STAT3 | 9.1% |
| 6 | Angiogenesis (P00005) | 5 | CTNNB1, ITGB1, PIK3R1, STAT3, RAC1 | 7.6% |
| 7 | Cytoskeletal regulation by Rho GTPase (P00016) | 5 | ARPC2, MYH9, MYH10, RAC1 | 7.6% |
| 8 | FGF signaling pathway (P00021) | 4 | YWHAH, PIK3C2A, YWHAQ, RAC1 | 6.1% |
| 9 | PDGF signaling pathway (P00047)* | 4 | JAK1, GAB1, PIK3R1, STAT3 | 6.1% |
| 10 | Axon guidance mediated by netrin (P00009) | 3 | PIK3C2A, PIK3R1, RAC1 | 4.5% |
| 11 | Insulin/IGF pathway-protein kinase B signaling cascade (P00033)* | 3 | PIK3C2A, IGF1R, PIK3R1 | 4.5% |
| 12 | p53 pathway (P00059) | 3 | HMGB1, PIK3C2A,PIK3R1 | 4.5% |
| 13 | p53 pathway feedback loops 2 (P04398) | 3 | CTNNB1, PIK3C2A, PIK3R1 | 4.5% |
| 14 | VEGF signaling pathway (P00056)* | 3 | PIK3C2A, PIK3R1, RAC1 | 4.5% |
| 15 | T cell activation (P00053) | 3 | PIK3R1, RAC1 | 4.5% |
| 16 | JAK/STAT signaling pathway (P00038)* | 2 | JAK1, STAT3 | 3.0% |
| 17 | Interleukin signaling pathway (P00036)* | 2 | STAT3 | 3.0% |
| 18 | Hypoxia response via HIF activation (P00030)* | 2 | PIK3C2A, PIK3R1 | 3.0% |
| 19 | Ras Pathway (P04393) | 2 | STAT3, RAC1 | 3.0% |
| 20 | TGF-beta signaling pathway (P00052) | 2 | TGFBR2, BMPR2 | 3.0% |
| 21 | Endothelin signaling pathway (P00019) | 2 | PIK3C2A, PIK3R1 | 3.0% |
| 22 | Parkinson disease (P00049) | 2 | YWHAH, YWHAQ | 3.0% |
| 23 | p38 MAPK pathway (P05918)* | 2 | IL1R1, RAC1 | 3.0% |
| 24 | Nicotinic acetylcholine receptor signaling pathway (P00044) | 2 | MYH9, MYH10 | 3.0% |
| 25 | Axon guidance mediated by Slit/Robo (P00008) | 1 | RAC1 | 1.5% |
| 26 | Axon guidance mediated by semaphorins (P00007) | 1 | RAC1 | 1.5% |
| 27 | Apoptosis signaling pathway (P00006)*# | 1 | 1.5% | |
| 28 | Alzheimer disease-presenilin pathway (P00004) | 1 | CTNNB1 | 1.5% |
| 29 | Interferon-gamma signaling pathway (P00035)* | 1 | JAK1 | 1.5% |
| 30 | Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade (P00032)*# | 1 | IGF1R | 1.5% |
| 31 | Nicotine pharmacodynamics pathway (P06587) | 1 | PPP1CB | 1.5% |
| 32 | Huntington disease (P00029) | 1 | RAC1 | 1.5% |
| 33 | Wnt signaling pathway (P00057)* | 1 | CTNNB1 | 1.5% |
| 34 | PI3 kinase pathway (P00048)* | 1 | PIK3R1 | 1.5% |
| 35 | Cadherin signaling pathway (P00012)* | 1 | CTNNB1 | 1.5% |
| 36 | Dopamine receptor mediated signaling pathway (P05912) | 1 | PPP1CB | 1.5% |
| 37 | B cell activation (P00010)* | 1 | RAC1 | 1.5% |
Note:
* indicates pathways that are part of Toll-like receptor, inflammation and NFkB signaling.
# indicates pathways that are part of apoptosis pathways.