Table 3.

Discriminatory accuracy and cut-off values for triglyceride/HDL-C ratio, LAP, VAI, and TyG index in identifying subjects with insulin resistance defined as the bottom quartile of M_FFM values

	Sensitivity	Specificity	Positive predictive value	Negative predictive value	AUC (95% CI)	P value*	Diagnostic likelihood ratio (+)	Youden index	Cut-off
Triglyceride/HDL-C ratio	0.82	0.48	0.35	0.89	0.693 (0.646 to 0.729)	0.01	1.60	0.309	0.57
LAP index	0.70	0.65	0.40	0.86	0.728 (0.692 to 0.762)	NA	2.00	0.350	3.84
VAI	0.73	0.54	0.35	0.86	0.688 (0.650 to 0.724)	0.002	1.61	0.276	0.34
TyG index	0.59	0.70	0.40	0.84	0.688 (0.650 to 0.723)	0.005	2.04	0.305	9.36

*P value of receiver operating characteristic (ROC) test between each marker and benchmark LAP index, respectively.

AUC, area under the ROC curve; HDL-C, high-density lipoprotein cholesterol; LAP, lipid accumulation product; NA, not applicable; TyG, triglycerides × fasting glucose; VAI, visceral adiposity index.