Table 5.

Discriminatory accuracy and cut-off values for triglyceride/HDL-C ratio, LAP, VAI, and TyG index in identifying individuals with subclinical vascular damage

	Sensitivity	Specificity	Positive predictive value	Negative predictive value	AUC (95% CI)	P value*	Diagnostic likelihood ratio (+)	Youden index	Cut-off
Vascular atherosclerosis defined as IMT>0.9 mm
Triglyceride/HDL-C ratio	0.950	0.412	0.134	0.989	0.701 (0.656 to 0.742)	0.15	1.62	0.362	0.499
LAP index	0.900	0.494	0.146	0.981	0.742 (0.699 to 0.782)	NA	1.78	0.394	3.623
VAI	0.750	0.601	0.153	0.962	0.705 (0.661 to 0.747)	0.12	1.88	0.351	0.484
TyG index	0.825	0.592	0.163	0.972	0.739 (0.696 to 0.779)	0.91	2.02	0.417	9.192
Increased vascular stiffness defined as pulse pressure >60 mm Hg
Triglyceride/HDL-C ratio	0.662	0.473	0.169	0.897	0.551 (0.510 to 0.590)	0.001	1.26	0.136	0.659
LAP index	0.721	0.500	0.189	0.917	0.614 (0.574 to 0.652)	NA	1.44	0.221	3.664
VAI	0.744	0.415	0.171	0.909	0.562 (0.522 to 0.602)	0.001	1.27	0.276	0.177
TyG index	0.744	0.417	0.171	0.910	0.579 (0.539 to 0.618)	0.04	1.28	0.161	8.987

*P value of receiver operating characteristic (ROC) test between each marker and benchmark LAP index, respectively.

AUC, area under the ROC curve; HDL-C, high-density lipoprotein cholesterol; IMT, intima-media thickness; LAP, lipid accumulation product; NA, not applicable; TyG, triglycerides × fasting glucose; VAI, visceral adiposity index.