Table 2.
Widespread increases in functional connectivity of the vmPFC in OCD.
| Connected regions, OCD > Control |
BA | Cluster size, voxels |
z-score, peak |
Primary peak, coordinates |
|---|---|---|---|---|
| Right caudate | 48 | 59 | 4.00 | 10, 12, 10 |
| Fusiform gyrus | 37 | 43 | 3.98 | 48, –52, –8 |
| Inferior frontal gyrus | 44 | 36 | 3.95 | −58, 6, 8 |
| Left thalamus | 50 | 67 | 3.76 | −18, –20, –2 |
| Superior frontal gyrus | 8 | 62 | 3.75 | 12, 28, 42 |
| Visual association cortex | 19 | 44 | 3.67 | 22, –68, –8 |
| Superior temporal gyrus | 22 | 23 | 3.66 | 58, –36, 10 |
| Dorsomedial PFC | 10 | 11 | 3.54 | 48, 44, 20 |
| Cerebellum | n/a | 35 | 3.50 | 34, –44, –24 |
| Temporal cortex | 21 | 13 | 3.48 | −52, –48, 6 |
| Primary motor cortex | 4 | 15 | 3.44 | 52, –6, 12 |
| Cerebellum | n/a | 46 | 3.43 | 20, –50, –32 |
| Fusiform | 36 | 10 | 3.21 | 28, –32, –14 |
vmPFC: ventromedial prefrontal cortex; OCD: obsessive-compulsive disorder; BA: Brodmann’s area; PFC: prefrontal cortex.
Brain regions show significant increases in connectivity with the vmPFC seed at (−2, 26, −2). Thresholds were set at p < 0.001 (uncorrected), cluster threshold = 10 voxels.