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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Nat Catal. 2019 Sep 23;2(11):977–985. doi: 10.1038/s41929-019-0348-x

Fig. 1. Design of a minimalistic F–Zn(ii) biocatalyst through bioinspiration from structural insights of CA II.

Fig. 1

a, Structure of human carbonic anhydrase (CA II; PDB entry 1CA2), which displays a zinc-coordinated cross-β-sheet catalytic centre that is involved in the catalysis of ester hydrolysis and interconversion of carbon dioxide to bicarbonate and proton. b, Chemical structure of phenylalanine and the monomeric 2:1 (F:Zn(ii)) complex and schematic of the nucleation and growth mechanism for rapid F–Zn(ii) co-assembly with CA-like catalytic activity.