Fig. 2.

LPC-specific deletion of FADD prevents hepatocarcinogenesis in TAK1^LPC-KO mice. a Representative liver images from 28-week-old mice with the indicated genotypes. b Representative images of Masson´s trichrome stained liver sections from 28-week-old mice with the indicated genotypes. HCC is outlined and marked with an asterisk. c Histopathological evaluation of hepatocarcinogenesis in samples of 21-to-28-week-old mice. d Quantification of dysplastic nodules/foci per lamella in liver sections of mice with the indicated genotype. e–f Liver:body weight (LW/BW) ratio (e) and serum ALT and total Bilirubin levels in 28-week-old mice with the indicated genotypes (f). The number of mice analyzed (n) is indicated in every graph. All graphs show mean values of the individual data points. *p < 0.05, **p < 0.01, ***p < 0.005. Bars: a 1 cm; b 100 μm