Figure 2.
In vitro binding/uptake of fluorescent targeted liposomes displaying 160 or 161 to CHO cells expressing Siglec-8 and -F. Cells were treated with 20 μM fluorescent targeted liposomes (2 mol% of 160 or 161) at 37 °C for 1 hour. Liposome binding was assessed by flow cytometry. Low binding to some cells reflects loss of Siglec expression (see Figure S4).