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. 2019 Nov 12;11:313. doi: 10.3389/fnagi.2019.00313

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Copyright © 2019 Meng, Yan, Lei, Wan, Hou, Sun and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Localization, enzyme activity, and function of the sirtuin family. SIRT1, SIRT6, and SIRT7 are mainly located in the nucleus and regulate DNA repair and gene transcription. SIRT2 is mainly located in the cytosol and plays an important role in the regulation of the cell cycle. SIRT3, SIRT4, and SIRT5 are known as mitochondrial sirtuins and are involved in the regulation of mitochondrial functions.