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. 2019 Nov 12;13:507. doi: 10.3389/fncel.2019.00507

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Copyright © 2019 Hua, Yang, Chen, Zhang, Hu and Fan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effects of PNU-282987 on MPP⁺-induced increase of TUNEL⁺/GFAP⁺ cells in primary cultured astrocytes. (A) Astrocytes were incubated with primary antibody against GFAP and TUNEL. Images were collected on the fluorescence microscopy. The yellow arrows show significantly increased expression of TUNEL staining in the nucleus of astrocytes. (B) Quantitative analysis of PNU-282987-induced protection as measured by TUNEL⁺/GFAP⁺ staining produced a significant neuroprotective effect. ^∗∗∗p < 0.001 vs. control group; ^##p < 0.01 vs. MPP⁺ treatment group; ^$$$p < 0.001 vs. PNU-282987 treatment group. Con, control; PNU, PNU-282987; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; GFAP, glial fibrillary acidic protein.