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. 2019 Nov 12;13:507. doi: 10.3389/fncel.2019.00507

FIGURE 6.

FIGURE 6

The effects of α7nAChR deficiency on MPP+-induced expression of the JNK-p53-caspase-3 signaling pathway in primary cultured astrocytes. (A) Representative immunoblot of p-JNK, JNK, p-p53, p53, cleaved-caspase-3, caspase-3, Bax, and Bcl-2 in WT and KO cultured astrocytes. (B) Quantitation of p-JNK and JNK levels at baseline and in response to MPP+ and PNU-282987. (C) Quantitation of p-p53 and p53 levels at baseline and in response to MPP+ and PNU-282987. (D) Quantitation of cleaved-caspase-3 and caspase-3 levels at baseline and in response to MPP+ and PNU-282987. (E) Quantitation of Bax and Bcl-2 levels at baseline and in response to MPP+ and PNU-282987. Data are presented as mean ± SEM of three independent experiments. ∗∗∗p < 0.001, ∗∗p < 0.01, and ∗p < 0.05 vs. corresponding control group; ##p < 0.01 vs. corresponding MPP+ treatment group; $$p < 0.01 vs. PNU-282987-treated WT group. WT, astrocyte from wild-type mice; KO, astrocytes from α7nAChR KO mice; PNU, PNU-282987.