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. 2019 Oct 23;145(12):2911–2920. doi: 10.1007/s00432-019-03040-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Analysis of CTCs based on cell size and correlation of small cell CTCs with PFS. a Images of small and large CTCs in advanced lung cancer patients. Comparing to the size of WBCs (white arrow), an small (≤ 5um WBC) triploid CTCs as well as an large (≥ 5um WBC) multiploid CTCs are indicated by orange and red arrow. b Correlation of small cell CTCs with PFS. Pretreatment patients with small cell CTCs ≥ 2/6 ml had a PFS significantly shorter than patients with small cell CTCs < 2/6 ml (p = 0.017)