Table 2.

Univariate and multivariate analysis for prognosis predictors in advanced lung cancer patients

Variables	Univariate analysis		Multivariate analysis
	HR(95% CI)	p	HR(95% CI)	p
Age ≥ 60 vs. < 60	0.956 (0.399–2.291)	0.919
Gender male vs. female	0.757 (0.407–1.408)	0.757
PS 1–2 vs. 0	2.701 (0.947–7.702)	0.063
Smoking history yes vs. no	1.021 (0.425–2.452)	0.963
Pathological type SCLC vs. ADC	0.674 (0.350–1.298)	0.238
TNM stage III vs. VI	2.322 (1.182–4.561)	0.014	2.349 (1.128-4.889)	0.022
Liver metastasis yes vs. no	3.923 (1.593–9.662)	0.003	1.641 (0.602–4.474)	0.333
Bone metastasis yes vs. no	1.033 (0.403–2.650)	0.946
Brain metastases yes vs. no	0.935 (0.223–3.912)	0.927
Treatment response PR vs. SD + PD	1.762 (0.941–3.299)	0.077
Baseline CTCs ≥ 5 vs. < 5	1.119 (0.607–2.066)	0.718
Baseline small cell CTCs ≥ 2 vs. < 2	2.208 (1.133–4.303)	0.020	1.262 (0.580–2.747)	0.558
Baseline triploid CTCs ≥ 2 vs. < 2	2.310 (1.206–4.424)	0.012	1.764 (0.827–3.579)	0.142
Baseline Vim+ CTCs ≥ 1 vs. 0	3.358 (1.600–7.049)	0.001	2.756 (1.239–6.131)	0.013