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. 2019 Nov 12;13:254. doi: 10.3389/fnbeh.2019.00254

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Copyright © 2019 Meir Drexler, Merz, Lissek, Tegenthoff and Wolf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental timeline. The testing was conducted on three consecutive days separated by 24-h intervals: fear acquisition training on day 1; pharmacological treatment and memory reactivation on day 2; extinction training, reinstatement and reinstatement test on day 3. The procedure was identical for the three groups on days 1 and 3 and differed between the three groups only on day 2, in which memory was either reactivated (RE+CORT, RE groups) or not reactivated (CORT group) following the administration of cortisol (RE+CORT, CORT) or placebo (RE). Skin conductance responses (SCR; illustrated by the palm) served as a measure of conditioned fear, and were recorded during all experimental phases. Seven saliva samples (illustrated by the saliva collecting devices) were used to assess salivary cortisol, and were collected during the three experimental days. CS, conditioned stimulus; CSM, conditioned stimulus modified. Bolts, representation of the unconditioned stimulus (UCS).