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. 2019 Nov 12;13:254. doi: 10.3389/fnbeh.2019.00254

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Copyright © 2019 Meir Drexler, Merz, Lissek, Tegenthoff and Wolf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Day 3: Analyses of the reinstatement test to the original stimuli compared the mean (± SEM) SCR to the conditioned stimuli (CS+, CS−) in the late phase of extinction (mean of the last five trials; late extinction CS+: RE+CORT: 0.08 ± 0.02; RE: 0.13 ± 0.03; CORT: 0.09 ± 0.02; late extinction CS−: RE+CORT: 0.09 ± 0.03; RE: 0.14 ± 0.03; CORT: 0.12 ± 0.03) and the first trial after reinstatement (first reinstatement trial CS+: RE+CORT: 0.10 ± 0.03; RE: 0.17 ± 0.04; CORT: 0.21 ± 0.05; first reinstatement trial CS−: RE+CORT: 0.06 ± 0.02; RE: 0.14 ± 0.04; CORT: 0.06 ± 0.03) in the three experimental groups (N = 73; RE+CORT group: n = 24, RE group: n = 25, CORT group: n = 24). In the CORT group, differential reinstatement (i.e., higher SCR after the reinstatement shocks only to CS+) was found (*p < 0.05). No reinstatement was found in the two reactivation groups, RE+CORT and RE (all p < 0.01).