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. 2019 Nov 12;13:254. doi: 10.3389/fnbeh.2019.00254

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Copyright © 2019 Meir Drexler, Merz, Lissek, Tegenthoff and Wolf.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Day 3: Analyses of the reinstatement test to the modified stimuli compared the mean (± SEM) SCR to the stimuli in the late phase of extinction (mean of last 5 trials of the original CS+ or CS−; late extinction original CS+: RE+CORT: 0.08 ± 0.02; RE: 0.13 ± 0.03; CORT: 0.09 ± 0.02; late extinction original CS−: RE+CORT: 0.09 ± 0.03; RE: 0.14 ± 0.03; CORT: 0.12 ± 0.03) and the first trial after reinstatement (modified stimulus, CS+M or CS−M; first reinstatement trial CS+M: RE+CORT: 0.11 ± 0.03; RE: 0.18 ± 0.04; CORT: 0.18 ± 0.04; first reinstatement trial CS−M: RE+CORT: 0.16 ± 0.05; RE: 0.12 ± 0.04; CORT: 0.18 ± 0.05). The analysis revealed a generalized reinstatement (i.e., to both CS+M and CS−M; **p = 0.005). Since no group effect or interaction were found, the figure presents all three experimental groups combined (N = 73; RE+CORT group: n = 24, RE group: n = 25, CORT group: n = 24).