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. 2019 Nov 18;8(12):68. doi: 10.1038/s41389-019-0177-4

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Pancreatic cancer cells with overexpression of CD133 in MIA-PACA2 cells (a) as well as endogenous CD133+ cells isolated from KPC tumors showed increased GAS5 expression (b). Similarly, exposure to hypoxia (c), nutritional stress (d) and chemotherapy (e) increased GAS5 expression. Silencing CD133 in CD133Hi cells decreased the expression of GAS5 (f). Further, inhibition of GAS5 by siRNA increased proliferation (g) and increased nucleic acid synthesis (h).