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. 2019 Nov 18;9:16978. doi: 10.1038/s41598-019-53334-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-Pr-VAR2CSA antibodies recognize VAR2CSA from different P. falciparum strains. Immune recognition of erythrocytes infected by different P. falciparum parasite strains (NF54, FCR3, and 7G8) selected for different adhesive phenotypes (CSA and CD36) by immunisation-induced antibodies directed towards P. reichenowi VAR2CSA. Infected erythrocytes were incubated with rat sera (a) or rabbit sera (b) diluted 1:10. Erythrocyte-bound IgGs were detected using an anti-rat IgG or an anti-rabbit IgG specific antibody PE-conjugated. Cells were then subjected to flow cytometry analysis. Results are expressed as the fold-increase in geometrical mean fluorescence intensity obtained with immune (Day 63) sera compared to pre-immune sera. Error bars represent the standard deviation of 3 independent experiments.