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. 2019 Nov 18;9:16978. doi: 10.1038/s41598-019-53334-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Anti-Pr-VAR2CSA antibodies inhibit the interaction between CSA and erythrocytes infected with different P. falciparum VAR2CSA strains. Inhibition of P. falciparum-infected erythrocytes binding to CSA by immunisation-induced antibodies directed towards Pr-VAR2CSA. Erythrocytes infected by different P. falciparum parasite strains (NF54, FCR3, and 7G8) selected for CSA adhesive phenotype were incubated with rat sera (a) or rabbit sera (b) diluted 1:10 and then plated on CSA-coated plates. CSA-binding inhibition was assessed by relative quantification of IEs remaining bound to the plate surface. Error bars represent the standard deviation of values obtained from three independent replicates.