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. 2019 Nov 18;9:302. doi: 10.1038/s41398-019-0643-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–d Protein levels, by western blot and relative to β-actin, of MRPL40, VDAC, SDHA, MT-ND1, cytochrome b, and COX1 in iPSC-derived neurons. While nuclear-encoded VDAC and SDHA were unchanged, the mitochondria-encoded proteins MT-ND1, cytochrome b, and COX1 were significantly reduced. e Quantitative PCR of MRPL40, VDAC, MT-ND1, cytochrome b, and COX1 shows decreased expression of MRPL40 but no change of VDAC, MT-ND1, cytochrome b, and COX1 in 22qSZ relative to control. f No difference of mitochondrial DNA copy number between 22qSZ and control in iPSC-derived neurons at differentiation day 21. N = 5 for control, N = 4 for 22qSZ; * indicates p < 0.05. NS—not significant.