Fig. 2. FUMA results of the overrepresented gene-sets retrieved from the functional enrichment analysis of the 97 differentially expressed proteins with MPH treatment in the cortex of Wistar-Kyoto rats.

The blue bars represent the enrichment P-value (-log10 adjusted) after FDR correction considering the number of gene-sets tested per category. The red bars indicate the proportion of overlapping inputted genes according to the size (number of genes) of each gene-set. The orange squares show the inputted genes that are part of the enriched gene-sets. (a) Significantly enriched gene-sets from the Gene Ontology (GO)—Biological Process category. (b) Significantly enriched gene-sets from the Reactome category. (c) Significantly enriched gene-sets from the Kyoto Encyclopedia of Genes and Genomes (KEGG) category. *Respiratory electron transport ATP synthesis by chemiosmotic coupling and heat production by uncoupling proteins.