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. 2019 Nov 18;9:16970. doi: 10.1038/s41598-019-53174-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-4715-3p is downregulated in gastric cancer. (A) AURKA is a predicted target gene of miR-4715-3p in 3 different databases (www.TargetScan.org, www.microRNA.org, and www.miRDB.org) (left panel); a schematic drawing shows the specific binding sites of miR-4715-3p on AURKA 3′UTR (right panel). (B) AURKA mRNA is overexpressed in gastric cancer tissue samples. (C) qRT-PCR data showing miR-4715-3p expression levels in human gastric cancer (GC, n = 33) and non-tumor normal gastric (NG, n = 49) tissue samples. The horizontal bar indicates the median, Mann–Whitney test. (D) qRT-PCR data of miR-4715-3p expression in 15 human normal gastric samples and 6 human gastric cancer cell lines. (E) Kaplan–Meier analysis of AURKA-related overall survival in 876 human gastric cancer patients. ***P < 0.001. (F) Kaplan–Meier analysis of miR-4715-3p-related overall survival in 431 human gastric cancer patients. *P < 0.043.