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. 2019 Nov 18;9:16970. doi: 10.1038/s41598-019-53174-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-4715-3p suppressed cellular proliferation of OE33 spheroids, enhanced polyploidy, and altered cell cycle progression. (A,B) OE33 cells were transfected with miR-4715-3p mimic for 48 h, then cell cycle progression was analyzed with flow cytometry. After 48 h, miR-4715-3p reconstitution significantly enhanced polyploidy in OE33 cells. Reconstitution of miR-4715-3p significantly reduced spheroids’ forming ability of OE33 cells (C–E) Western blot analysis of OE33 spheroids shows significant down regulation of AURKA after miR-4715-3p reconstitution.