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. 2019 Nov 18;9:16970. doi: 10.1038/s41598-019-53174-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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miR-4715-3p is hypermethylated in UGCs samples. (A) A schematic drawing shows the CpG sites in miR-4715-3p and pyrosequencing assay location. Each vertical bar represents a CpG site. DNA methylation levels of 5 CpG sites in the 1,000 bp upstream of miR-4715-3p was quantified by pyrosequencing. (B) Representative pyrosequencing profiles of normal and gastric cancer tissue samples. (C) Quantification of miR-4715-3p methylation in normal and gastric cancer tissue samples (D,E) Representative pyrosequencing profiles of OE33 and MKN45 cells. (F,G) AURKA mRNA and miR-4715-3p expression levels in OE33 and MKN45 cells treated with 5-Aza-2′-deoxycytidine (Decitabine), 5 µM for 72 h.