Table 3.

Univariate and multivariate analysis for progression free survival (n = 227).

	Univariate			Multivariate
	Beta	HR (95%CI)	P*	Beta	HR (95%CI)	P**
M1 at diagnosis	−0.475	0.62 (0.46–0.84)	0.002	−0.384	0.68 (0.49–0.94)	0.02
ER negative	0.691	1.99 (1.43–2.78)	<0.001	0.360	1.43 (0.96–2.15)	0.08
PR positive	−0.590	0.55 (0.41–0.75)	<0.001	−0.340	0.71 (0.50–1.02)	0.06
HER2+	0.065	1.07 (0.76–1.50)	0.71	—	—	—
ECOG 0–1	−0.487	0.61 (0.43–0.88)	0.008	−0.426	0.65 (0.43–0.98)	0.04
NLR (continuous)	0.044	1.045 (1.005–1.086)	0.03	0.028	1.029 (0.984–1.075)	0.21
NLR high (>2.32)	0.117	1.12 (0.84–1.50)	0.43	—	—	—
>=2 locations	−0.372	0.69 (0.51–0.92)	0.01	—	—	—
CNS metastasis	−0.258	0.77 (0. 42–1.42)	0.41	—	—	—
Visceral metastasis	0.514	1.67 (1.24–2.26)	0.001	0.291	1.34 (0.97–1.84)	0.08
Visceral crisis	1.003	2.73 (1.70–4.37)	<0.001	0.505	1.66 (0.97–2.84)	0.07