. 2019 Nov 18;9:16972. doi: 10.1038/s41598-019-53546-y

Table 3.

Association of longitudinal risk profile trajectory clusters with different adipose tissue traits and impact of additional adjustment for risk factors obtained at Exam 1 or Exam 3.

outcome	Model	Cluster I	Cluster II			Cluster III
outcome	Model		estimate	95%-CI	p-value	estimate	95%-CI	p-value
TAT	fully adjusted	Ref.	3.90	[2.89, 4.91]	<0.01	9.49	[8.20, 10.78]	<0.01	R² = 0.54
	fully adjusted + risk profile Exam 1	Ref.	3.21	[2.14, 4.29]	<0.01	6.25	[4.73, 7.77]	<0.01	R² = 0.65
	fully adjusted+risk profile Exam 3	Ref.	0.39	[−0.26, 1.04]	n.s	0.96	[0.09, 1.82]	0.03	R² = 0.89
VAT	fully adjusted	Ref.	1.30	[0.84, 1.75]	<0.01	3.32	[2.74, 3.90]	<0.01	R² = 0.63
	fully adjusted + risk profile Exam 1	Ref.	1.16	[0.63, 1.69]	<0.01	2.62	[1.87, 3.37]	<0.01	R² = 0.66
	fully adjusted + risk profile Exam 3	Ref.	0.17	[−0.30, 0.65]	n.s	0.90	[0.26, 1.53]	<0.01	R² = 0.76
SAT	fully adjusted	Ref.	2.60	[1.87, 3.34]	<0.01	6.16	[5.23, 7.10]	<0.01	R² = 0.48
	fully adjusted + risk profile Exam 1	Ref.	2.05	[1.30, 2.81]	<0.01	3.63	[2.56, 4.70]	<0.01	R² = 0.63
	fully adjusted + risk profile Exam 3	Ref.	0.22	[−0.26, 0.70]	n.s	0.06	[−0.59, 0.71]	n.s	R² = 0.87
RSFF	fully adjusted	Ref.	3.39	[1.02, 5.76]	<0.01	3.20	[0.18, 6.22]	0.04	R² = 0.29
	fully adjusted + risk profile Exam 1	Ref.	2.47	[−0.41, 5.35]	n.s	0.31	[−3.77, 4.39]	n.s	R² = 0.29
	fully adjusted + risk profile Exam 3	Ref.	0.19	[−2.80, 3.18]	n.s	−2.28	[−6.28, 1.72]	n.s	R² = 0.33
HFF	fully adjusted	Ref.	1.54	[1.27, 1.86]	<0.01	2.48	[1.93, 3.16]	<0.01	R² = 0.43
	fully adjusted + risk profile Exam 1	Ref.	1.51	[1.21, 1.90]	<0.01	2.23	[1.62, 3.03]	<0.01	R² = 0.47
	fully adjusted + risk profile Exam 3	Ref.	1.14	[0.91, 1.43]	n.s	1.32	[0.98, 1.79]	n.s	R² = 0.53
PFF	fully adjusted	Ref.	1.52	[1.26, 1.84]	<0.01	2.20	[1.73, 2.80]	<0.01	R² = 0.24
	fully adjusted + risk profile Exam 1	Ref.	1.52	[1.21, 1.92]	<0.01	1.82	[1.32, 2.51]	<0.01	R² = 0.26
	fully adjusted + risk profile Exam 3	Ref.	1.40	[1.10, 1.79]	<0.01	1.58	[1.15, 2.20]	<0.01	R² = 0.27

Estimates are derived from a linear regression model. Cluster I served as reference category, i.e. estimates describe the change in adipose tissue outcome that is associated with membership in Cluster II (or Cluster III) as compared to membership in Cluster I. Estimates for TAT, VAT, SAT and RSFF are given as β-coefficients. Estimates for HFF and PFF are back-transformed from log-transformation and are therefore given as %change of the geometric mean. The fully adjusted model is adjusted for age, sex, antihypertensive medication, lipid-lowering medication, smoking status, and validated diabetes.