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. 2019 Nov 12;9:1097. doi: 10.3389/fonc.2019.01097

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Copyright © 2019 Herath, Berthault, Thierry, Jdey, Lienafa, Bono, Noguiez-Hellin, Sun and Dutreix.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bone marrow myelogram. Wright–Giemsa staining of (A) sternal imprints and (B) bone marrow smears and (C) H&E staining of paraffin-embedded tibia. (D) Mean values of bone marrow myelogram (six animals) treated with various treatments (indicated in abscissa) and sacrificed at day 7 or day 21 after the third cycle. Samples were scored from 0 to 10 according to the following scale: poor (0–3), moderate (4–7), or good (8–10) indicating high, moderate, or no toxicity in erythroid (dark violet), myeloid (medium violet), and megakaryocyte score (dashed violet), and density (light violet).