Table 6.
Outcomes of the five-category-model for inferring smoking habits and smoking history from blood based on 13 CpGs
| Never versus former > 10 years cessation time versus former ≤ 10 years cessation time versus < 15 pack-years versus ≥ 15 pack-years | |||||
|---|---|---|---|---|---|
| Model building data set (N = 2939) | Never (N = 1243) | F > 10 year (N = 1021) | F ≤ 10 year (N = 311) | < 15PY (N = 154) | ≥ 15PY (N = 210) |
| Specificity | 0.712 | 0.777 | 0.979 | 0.987 | 0.967 |
| Sensitivity | 0.817 | 0.554 | 0.206 | 0.299 | 0.724 |
| AUC | 0.835 | 0.739 | 0.793 | 0.869 | 0.949 |
| Fivefold cross-validation | |||||
| Specificity | 0.711 ± 0.022 | 0.775 ± 0.036 | 0.977 ± 0.009 | 0.984 ± 0.009 | 0.963 ± 0.014 |
| Sensitivity | 0.809 ± 0.047 | 0.545 ± 0.040 | 0.199 ± 0.042 | 0.274 ± 0.128 | 0.695 ± 0.064 |
| AUC | 0.832 ± 0.014 | 0.731 ± 0.026 | 0.779 ± 0.018 | 0.855 ± 0.046 | 0.947 ± 0.016 |
| External replication in KORA (N = 1551) | Never (N = 675) | F > 10 year (N = 488) | F ≤ 10 year (N = 164) | < 15 PY (N = 55) | ≥ 15PY (N = 169) |
|---|---|---|---|---|---|
| Specificity | 0.534 | 0.830 | 0.994 | 0.994 | 0.979 |
| Sensitivity | 0.927 | 0.299 | 0.122 | 0.018 | 0.728 |
| AUC | 0.788 | 0.650 | 0.791 | 0.710 | 0.955 |
| Never versus former > 10 years cessation versus former ≤ 10 years cessation versus < 10 pack-years versus ≥ 10 pack-years | |||||
|---|---|---|---|---|---|
| Model building data set (N = 2939) | Never (N = 1243) | F > 10 year (N = 1021) | F ≤ 10 year (N = 311) | < 10 PY (N = 118) | ≥ 10PY (N = 246) |
| Specificity | 0.714 | 0.776 | 0.981 | 0.994 | 0.963 |
| Sensitivity | 0.817 | 0.554 | 0.193 | 0.220 | 0.772 |
| AUC | 0.835 | 0.739 | 0.794 | 0.863 | 0.948 |
| Fivefold cross-validation | |||||
| Specificity | 0.709 ± 0.023 | 0.774 ± 0.034 | 0.980 ± 0.006 | 0.992 ± 0.003 | 0.960 ± 0.008 |
| Sensitivity | 0.808 ± 0.045 | 0.542 ± 0.042 | 0.194 ± 0.043 | 0.206 ± 0.066 | 0.758 ± 0.067 |
| AUC | 0.831 ± 0.014 | 0.730 ± 0.027 | 0.780 ± 0.018 | 0.847 ± 0.047 | 0.946 ± 0.023 |
| External replication in KORA (N = 1551) | Never (N = 675) | F > 10 year (N = 488) | F ≤ 10 year (N = 164) | < 10 PY (N = 35) | ≥ 10PY (N = 189) |
|---|---|---|---|---|---|
| Specificity | 0.535 | 0.827 | 0.994 | 0.998 | 0.977 |
| Sensitivity | 0.926 | 0.299 | 0.110 | 0.000 | 0.683 |
| AUC | 0.788 | 0.651 | 0.791 | 0.694 | 0.943 |
Cross-validation analysis results are presented as mean ± standard deviation
AUC area under the curve, F former smokers in years cessation time, PY pack-years