Fig. 1.

Fenofibrate promotes the formation of very-long-chain sphingolipids. Pancreatic samples taken from 13-week-old mice were analysed by LC-MS to evaluate (a) total sulfatide content and (b) the amounts of individual sulfatide species (as pmol/mg protein). (c–f) The remaining lipidome was analysed using a shotgun lipidomics approach. Results are presented as mol %. (c) Total sphingomyelin, (d) sphingomyelin species, (e) total ceramide, (f) ceramide species. White bars, control; grey bars, fenofibrate. Data are shown as means ± SD; n = 4. *p < 0.05; **p < 0.01; ***p < 0.001 by two-tailed unpaired Student’s t test