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. 2019 Nov 12;9:1196. doi: 10.3389/fonc.2019.01196

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Copyright © 2019 Jiang, Zhang, Wang, Peng, Zhang, Wang, Han and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IR-780 induces immunogenic cell death (ICD) in vitro. (A) Graphical data show the released of ATP, HMGB1, and surface expression of CRT on viable CT26 cells after treated with the indicated concentration of IR-780 (n = 3). (B) Immunofluorescence detection of CRT and HSP90 expression on the surface of CT26 cells after treated with 10 mM IR-780 for 24 h; scale bars = 20 μm. (C, D) Flow cytometry analysis of DC maturation by the markers (CD80⁺CD86⁺ of CD11c⁺ cells) after the immature DCs were cultured with IR-780-treated CT26 cells (n = 3). (E) Flow cytometry analysis the expression of MHCII in the CD11c⁺ cell population after the immature DCs were cultured with IR-780-treated CT26 cells (n = 3). All the data are presented as mean ± SD. **p < 0.01.