Table 3.
Trends in extranodal diffuse large B-cell lymphoma incidence-based mortality rates (1988–2015): the SEER-9 registry database.
| Trend | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall (1988–2015) | 1 | 2 | 3 | ||||||||
| APC (95% CI) | P-value | Year | APC (95% CI) | P-value | Year | APC (95% CI) | P-value | Year | APC (95% CI) | P-value | |
| Overall | 0.9 (0.1 to 1.8) | 0.0 | 1988–1993 | 7.2 (2.4 to 12.1) | 0.0 | 1993–2015 | −0.4 (−0.8 to −0.0) | 0.0 | |||
| Age, y | |||||||||||
| ≤14 | −1.6 (−2.5 to −0.7) | 0.0 | 1988–2003 | −1.6 (−2.5 to −0.7) | 0.0 | ||||||
| 15–39 | −3.6 (−8.2 to 1.2) | 0.1 | 1988–1993 | 17.0 (3.1 to 32.9) | 0.0 | 1993–1997 | −19.5 (−39.5 to 7.1) | 0.1 | 1997–2015 | −5.0 (−7.7 to −2.1) | 0.0 |
| 40–64 | −1.6 (−2.8 to −0.4) | 0.0 | 1988–1995 | 5.7 (1.1 to 10.5) | 0.0 | 1995–2015 | −4.0 (−4.8 to −3.2) | 0.0 | |||
| 65–85+ | 1.2 (0.7 to 1.7) | 0.0 | 1988–2002 | 2.9 (2.1 to 3.7) | 0.0 | 2002–2015 | −0.6 (−1.3 to 0.1) | 0.1 | |||
| Sex | |||||||||||
| Male | 0.9 (0.0 to 1.8) | 0.0 | 1988–1993 | 7.1 (2.3 to 12.2) | 0.0 | 1993–2015 | −0.5 (−0.9 to −0.1) | 0.0 | |||
| Female | 0.6 (-0.2 to 1.4) | 0.1 | 1988–2001 | 2.7 (1.3 to 4.1) | 0.0 | 2001–2015 | −1.3 (−2.3 to −0.3) | 0.0 | |||
| Race | |||||||||||
| White | 0.9 (−0.1 to 2.0) | 0.1 | 1988–1991 | 9.7 (0.7 to 19.5) | 0.0 | 1991–2002 | 0.9 (−0.1 to 2.0) | 0.1 | 2002–2015 | −1.1 (−1.7 to −0.4) | 0.0 |
| Black | −0.5 (−1.8 to 0.9) | 0.5 | 1988–2015 | −0.5 (−1.8 to 0.9) | 0.5 | ||||||
| Other | −0.0 (−0.9 to 0.9) | 1.0 | 1988–2015 | −0.0 (−0.9 to 0.9) | 1.0 | ||||||
| Ann Arbor Stage | |||||||||||
| I/II | 0.9 (0.1 to 1.7) | 0.0 | 1988–2000 | 4.0 (2.4 to 5.5) | 0.0 | 2000–2015 | −1.5 (−2.3 to −0.6) | 0.0 | |||
| III/IV | 2.4 (−0.2 to 5.2) | 0.1 | 1988–1990 | 28.5 (−11.3 to 86.0) | 0.2 | 1990–2015 | 0.6 (0.1 to 1.1) | 0.0 | |||
| Unknown | −4.2 (−5.1 to −3.3) | 0.0 | 1988–2015 | −4.2 (−5.1 to −3.3) | 0.0 | ||||||
| Site | |||||||||||
| Head/Neck | 0.7 (−0.9 to 2.3) | 0.4 | 1988–1993 | 9.2 (0.2 to 19.1) | 0.0 | 1993–2015 | −1.2 (−1.9 to −0.4) | 0.0 | |||
| Skin and soft tissue | 1.3 (−0.4 to 2.9) | 0.1 | 1988–2004 | 3.3 (1.2 to 5.5) | 0.0 | 2004–2015 | −1.6 (−4.5 to 1.3) | 0.3 | |||
| Gastrointestinal tract | −0.6 (−1.6 to 0.4) | 0.2 | 1988–1993 | 4.6 (−0.7 to 10.2) | 0.1 | 1993–2015 | −1.8 (−2.3 to −1.3) | 0.0 | |||
| Genitourinary tract | 1.2 (−0.3 to 2.6) | 0.1 | 1988–2015 | 1.2 (−0.3 to 2.6) | 0.1 | ||||||
| Skeletal tissue | 0.8 (−0.5 to 2.2) | 0.2 | 1988–2015 | 0.8 (−0.5 to 2.2) | 0.2 | ||||||
| Respiratory system | 1.0 (−0.8 to 2.8) | 0.3 | 1988–2015 | 1.0 (−0.8 to 2.8) | 0.3 | ||||||
| Hematologic system | 4.2 (2.6 to 5.7) | 0.0 | 1988–2015 | 4.2 (2.6 to 5.7) | 0.0 | ||||||
| Liver/pancreas | −0.1 (−3.6 to 3.5) | 0.9 | 1988–2011 | 3.4 (1.4 to 5.5) | 0.0 | 2011–2015 | −18.4 (−34.9 to 2.4) | 0.1 | |||
| Breast tissue | 0.3 (−1.4 to 1.9) | 0.8 | 1989–2015 | 0.3 (−1.4 to 1.9) | 0.8 | ||||||
| Other | 2.1 (0.6 to 3.6) | 0.0 | 1988–2015 | 2.1 (0.6 to 3.6) | 0.0 | ||||||