This is the first application of the Swedish Institute for Health Economics Cohort Model of T2D, a validated and transparent model, in assessing the cost effectiveness of semaglutide versus dulaglutide from a Canadian societal perspective, incorporating both a simplified base-case and an alternative scenario analysis.

Semaglutide is demonstrably a cost-effective treatment option versus dulaglutide in patients with T2D inadequately controlled on metformin monotherapy, providing evidence to support decision makers in the Canadian healthcare system in recommending semaglutide as a glucagon-like peptide-1 receptor agonist for reimbursement.