Table 3.

Studies reporting supportive care costs in LOPD patients, including inflation and currency adjustment

Author, year	Currency	Country	Costs included	Reported mean annual costs	Inflation-adjusted mean annual costs from data year to 2017a	Currency and inflation-adjusted mean annual costs (2017 USD)a
Kanters et al. (2011) [31]b	2009 euros	Netherlands	Medical: Hospital days, ICU, nursing home, ambulatory care, home care, medication, tests, procedures, devices Direct non-medical: Transportation, other non-medical costs Indirect: informal care, productivity losses	Overall: €22,475 Direct medical: €13,679 Direct non-medical: €421 Indirect: €8374	Overall: €25,281 Direct medical: €15,387 Overall indirect: €9420 Indirect (no productivity): €6955	Overall: $28,489 Direct medical: $17,340 Overall indirect: $10,615 Indirect (no productivity): $7838
Wyatt et al. (2012) (adult) [35]	2011 GBP	UK	Medical: Hospital days, outpatient visits, day cases, accident and ED visits, GP visits, nurse visits, therapists Direct non-medical: Social workers, home help, care attendant, community support worker, housing worker	Overall: £6300 Direct medical: £4501 Direct non-medical: £1799	Overall: £6984 Direct medical: £4990 Overall indirect: £1994	Overall: $8989 Direct medical: $6422 Overall indirect: $2567
Wyatt et al. (2012) (child) [35]	2011 GBP	UK	Medical: Hospital days, outpatient visits, day cases, accident and ED visits, GP visits, nurse visits, therapists Direct non-medical: Social workers, home help, care attendant, community support worker, housing worker	Overall: £10,080 Direct medical: £10,023 Direct non-medical: £57	Overall: £11,175 Direct medical: £11,112 Overall indirect: £63	Overall: $14,382 Direct medical: $14,301 Overall indirect: $81

CPI consumer price index, ED Emergency department, GBP Great Britain pounds, GP general practitioner, ICU intensive care unit, LOPD late-onset Pompe disease, OECD Organisation for Economic Cooperation and Development, USD United States dollars

^aInflation-adjusted from data to year 2017 (inflation-adjusted to 2017 using average annual inflation rate per year reported by OECD for each country and inflated based on data year). OECD (2018), “Inflation consumer price index (CPI) (indicator).” 10.1787/eee82e6e-en (accessed on 17 July 2018). Inflation-adjusted currency converted to USD based on currency reported in the publication. OECD (2018), “Exchange rates (indicator).” 10.1787/037ed317-en (Accessed on 17 July 2018)

^bIndividual reported mean annual costs for Kanters et al. (2011) [31] do not exactly sum to the overall cost due to rounding