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. 2019 Nov 12;10:1151. doi: 10.3389/fneur.2019.01151

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Copyright © 2019 Gureviciene, Ishchenko, Ziyatdinova, Jin, Lipponen, Gurevicius and Tanila.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Intimate relationship between giant spikes and a seizure in a 9-month-old male APPswe/PS1dE9 mouse. Recording from one channel of a movable tetrode located in the CA1 pyramidal cell layer. (A) An overview of the recording session at a low time resolution. Time 0 is the seizure onset. During the first 40 min up to time −10 min in the figure, the mouse was in a constant movement and the LFP shows regular theta rhythm with overriding gamma oscillation (inset C, light blue). Then the mouse fell asleep and the LFP shows frequent giants spikes during ~10 min. The last giant spike is continuous with the onset of a 32-s generalized seizure (inset B, pink). The seizure ends with a total suppression of the LFP for ~40 s (inset D, light green).