Figure 2.
Example of three simple cortical spikes recorded from an APP/PS1 mouse. The top channel (right frontal screw, FCsR) was used as a reference in all spike analyses. Only the 3rd spike exceeded the threshold of 6 SD, and is marked with a red vertical line to help comparison of spike timing between channels. The first one from left (orange vertical line) reached the 6 SD threshold on the left frontal screw electrode (FCsL) and appeared simultaneously but smaller in amplitude on the right frontal screw channel. The second spike is visible on the right (preceding the red vertical line) hemisphere but not at all on the left. None of the spikes is linked with hippocampal spikes. FCsR, right frontal screw; FCm, medial frontal; FCsL, left frontal screw; THvp, thalamus; ventral posterior nucleus; THrt, thalamus; reticular nucleus; EMG, electromyogram; CA1p, CA1 of hippocampus; stratum pyramidale; CA1r, CA1; stratum radiatum. Scale bar, 200 ms.