Table 7. Toxicological findings observed in the two-generation reproductive study (rats).
| Dose | Parent: P, Offsprings: F1 | Parent: F1, Offsprings: F2 | |||
|---|---|---|---|---|---|
| Male | Female | Male | Female | ||
| Parent animals | 20000 ppm | ·Increases in absolute and relative weights of the liver | ·Increases in absolute and relative weights of the liver | ·Increases in absolute and relative weights of the liver | ·Increases in absolute and relative weights of the liver |
| ·Increases in absolute and relative weights of the adrenal gland | ·Increases in absolute and relative weights of the thyroid gland | ||||
| ·Centrilobular hepatocellular hypertrophy | |||||
| ≤2000 ppm | No toxicological finding | No toxicological finding | No toxicological finding | No toxicological finding | |
| Offsprings | ≤20000 ppm | No toxicological finding | No toxicological finding | No toxicological finding | No toxicological finding |