Table 8. Summary of genotoxicity studies (technical grade).

Test system		Cells/animals	Dose or concentration	Results
in vitro	Reverse mutation test	Salmonella typhimurium	20.5 to 5000 µg/plate (−S9)	Negative
		(TA98, TA100, TA1535, TA1537 strains)	[TA100, TA1535, WP2uvrA]
		Escherichia coli	10.2 to 2500 µg/plate (+S9)
		(WP2uvrA strain)	[TA98, TA1537]
			4.1 to 1000 µg/plate (+S9)
	Mouse lymphoma TK test	Mouse lymphoma cells	10 to 150 µg/mL (−S9)	Negative
		(L5178Y TK +/−)	10 to 60 µg/mL (+ S9)
	Chromosome aberration test	Human peripheral blood lymphocytes	114 to 365 µg/mL (−S9)	Negative
			174 to 450 µg/mL (+S9)
in vivo	Rodent micronucleus test	ICR mice (bone-marrow cells)	0, 500, 1000 and 2000 mg/kg bw	Negative
		(5 males in a group)	(Single oral dose by gavage)

Note) ^+/−S9: with/without exogenous metabolic activation