Table III.
Adverse effects and inadequate response reported with Gabapentinoids.
| Adverse effects observed in patients who completed the study (n=252) | |||
|---|---|---|---|
| Drugs | Adverse effects | n (%) | Mean dose ±SD (mg/d) |
| Pregabalin | Dizziness, Drowsiness, Somnolence | 58 (23) | 95.43±53.06 |
| Visual Blurring | 3 (1.19) | 125.00±90.14 | |
| Ataxia | 4 (1.58) | 56.25±10.83 | |
| Weight Gain | 1 (0.39) | 300 | |
| Gabapentin | Dizziness, Drowsiness, Somnolence | 10 (3.96) | 360±171.27 |
| Patients’ non-compliance due to severe adverse effects (n=28) | |||
| n (%) | Mean dose ±SD (mg/d) | ||
| Pregabalin | 15 (54) | 112.00±48.17 | |
| Gabapentin | 13 (46) | 375.68±189.70 | |
| Patients with inadequate response (n=24) | |||
| Pregabalin | 7 (29) | 126.21±49.20 | |
| Gabapentin | 17 (71) | 325.58±162.73 | |
| Lost to follow up (n=16) | |||
| Pregabalin | 4 (25) | 106.28±80.24 | |
| Gabapentin | 12 (75) | 384.38±177.64 | |