Table 2.
SI, GE and beta cell function
| Variable | Insulin AUC quartile | IFG | IGT | |||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |||
| SID (dl−4 kg−1 min−1 [pmol/l]−1) | 263.5 (225.9) | 155.4 (109.6)* | 123.0 (88.1)* | 64.1 (60.1)*†‡ | 113.5 (61.9)* | 19.8 (27.2)*†‡¶ |
| SIL (dl−4 kg−1 min−1 [pmol/l]−1) | 190.4 (113.4) | 109.9 (81.0)* | 68.9 (36.4)*† | 45.0 (33.3)*†¶ | 108.3 (88.1) | 27.3 (28.1)*†‡¶ |
| SI (dl−4 kg−1 min−1 [pmol/l]−1) | 472.0 (272.4) | 257.7 (166.8)* | 211.3 (94.8)* | 113.1 (90.0)*†‡¶ | 263.8 (96.9)* | 47.0 (48.6)*†‡¶ |
| GED (dl kg−1 min−1) | 0.027 (0.006) | 0.027 (0.006) | 0.025 (0.004) | 0.024 (0.003)* | 0.026 (0.003) | 0.022 (0.001)*†‡§¶ |
| GEL (dl kg−1 min−1) | 0.021 (0.025) | 0.017 (0.036) | 0.025 (0.004) | 0.024 (0.003) | 0.034 (0.017) | 0.015 (0.009) |
| GE (dl kg−1 min−1) | 0.046 (0.029) | 0.045 (0.038) | 0.050 (0.025) | 0.049 (0.024) | 0.059 (0.021) | 0.038 (0.009)†‡§¶ |
| Φb (10−9 min−1) | 2.5 (1.2) | 3.7 (2.3)* | 4.0 (2.2)* | 4.4 (3.1)* | 3.8 (1.9) | 3.9 (1.9)* |
| Φd (10−9) | 216.2 (268.6) | 327.9 (301.8) | 406.8 (455.1)* | 500.9 (440.8)* | 415.3 (186.2) | 330.6 (406.1) |
| Φs (10−9 min−1) | 33.1 (17.2) | 38.6 (23.1) | 43.2 (29.6)* | 51.4 (26.7)* | 52.8 (28.5) | 31.4 (18.6)§ |
| Φtot (10−9 min−1) | 34.7 (18.6) | 40.3 (25.1) | 44.7 (30.3)* | 52.8 (27.1)* | 54.6 (31.5) | 34.1 (20.1)§ |
| DI (10−14 dl−1 kg−1 min−2 [pmol/l]−1) | 3506 (3443) | 2165 (2038) | 1854 (1617)* | 1083 (1217)*† | 2143 (2398) | 345 (288)*†‡§¶ |
| Insulin clearance (l min−1 m−2) | 1.6 (0.9) | 1.2 (0.4)* | 1.1 (0.5)* | 0.7 (0.4)*†‡¶ | 1.2 (0.6)* | 0.9 (0.6)* |
Data are median (interquartile range)
*p < 0.05 vs Q1
†p < 0.05 vs Q2
‡p < 0.05 vs Q3
§p < 0.05 vs Q4
¶p < 0.05 vs IFG