Table 6.
Sex-specific SI, GE and beta cell function in normoglycaemic participants
| Variable | Women | Men | ||||||
|---|---|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | Q1 | Q2 | Q3 | Q4 | |
| SID (dl−4 kg−1 min−1 [pmol/l]−1) | 226.0 (149.1) | 142.9 (64.9)* | 104.7 (101.9)* | 67.3 (66.9)*†‡ | 382.6 (215.1) | 217.8 (136.3) | 118.8 (67.0)*† | 53.3 (66.2)*† |
| SIL (dl−4 kg−1 min−1 [pmol/l]−1) | 176.6 (116.4) | 87.2 (51.6)* | 66.3 (38.2)* | 44.3 (28.7)*† | 225.1 (135.1) | 166.1 (97.0) | 86.2 (36.9)*† | 50.7 (59.6)*† |
| SI (dl−4 kg−1 min−1 [pmol/l]−1) | 430.0 (274.1) | 225.0 (102.6)* | 168.2 (114.3)* | 115.7 (85.5)*† | 582.6 (361.0) | 350.1 (129.3) | 203.7 (101.5)*† | 116.6 (105.0)*† |
| GED (dl kg−1 min−1) | 0.027 (0.006) | 0.025 (0.004) | 0.025 (0.005) | 0.025 (0.003)* | 0.027 (0.007) | 0.027 (0.005) | 0.026 (0.005) | 0.025 (0.002) |
| GEL (dl kg−1 min−1) | 0.016 (0.026) | 0.027 (0.029) | 0.023 (0.037) | 0.025 (0.035) | 0.018 (0.018) | 0.022 (0.029) | 0.014 (0.014) | 0.023 (0.020) |
| GE (dl kg−1 min−1) | 0.043 (0.024) | 0.052 (0.031) | 0.050 (0.032) | 0.050 (0.037) | 0.045 (0.023) | 0.049 (0.029) | 0.042 (0.015) | 0.049 (0.019) |
| Φb (10−9 min−1) | 3.9 (2.6) | 3.3 (2.3) | 4.3 (2.3) | 4.3 (2.3) | 2.2 (0.7) | 3.2 (1.2) | 3.6 (3.4)* | 4.9 (3.7)*† |
| Φd (10−9) | 342 (223) | 330 (417) | 436 (367) | 484 (422) | 195 (147) | 277 (334) | 316 (406)* | 449 (524)* |
| Φs (10−9 min−1) | 30.5 (13.4) | 37.8 (17.2) | 39.1 (26.9) | 52.0 (23.3)* | 34.2 (17.6) | 36.7 (30.5) | 48.4 (24.6) | 49.8 (35.8) |
| Φtot (10−9 min−1) | 32.1 (13.1) | 38.5 (18.0) | 40.3 (26.5) | 53.7 (25.0)* | 35.3 (17.8) | 36.8 (31.7) | 48.7 (24.4) | 52.5 (39.1)* |
| DI (10−14 dl kg−1 min−2 [pmol/l]−1) | 2644 (2514) | 2048 (1259) | 1655 (2126) | 1129 (1618)* | 4439 (2944) | 2713 (2773) | 2022 (1338)* | 1128 (1384)*† |
| Insulin clearance (l min−1 m−2) | 1.7 (0.9) | 1.3 (0.4)* | 1.0 (0.5)* | 0.8 (0.4)*†‡ | 1.7 (0.5) | 1.2 (0.3) | 1.1 (0.4)* | 0.7 (0.4)*†‡ |
Data are median (interquartile range)
*p < 0.05 vs Q1
†p < 0.05 vs Q2
‡p < 0.05 vs Q3