Table 1.
Baseline Characteristics At Cycle Level
| Characteristic | Letrozole (n=1569) | HMG (n=1827) | Letrozole + HMG (n=2505) | P-Valuea | P-Valueb | P-Valuec |
|---|---|---|---|---|---|---|
| Maternal age (year) | 35.03±3.88 | 34.46±4.24 | 35.48±4.59 | 0.002 | <0.001 | 0.048 |
| Duration of infertility (years) | 3.73±2.85 | 3.62±2.87 | 3.69±2.82 | 0.846 | 0.693 | 0.865 |
| BMI of women | 23.51±4.21 | 23.39±4.83 | 23.67±4.93 | 0.529 | 0.167 | 0.873 |
| Day 3 FSH (mIU/mL) | 4.09(0.17–9.97) | 4.13(0.84–9.98) | 4.17(0.32–9.99) | 0.482 | 0.851 | 0.186 |
| Day 3 LH (mIU/mL) | 4.98(0.11–18.94) | 4.92(0.17–19.01) | 4.96(0.94–17.32) | 0.239 | 0.694 | 0.481 |
| Day 3 E2 (pg/mL) | 34.00(10.00–85.00) | 33.00(10.00–90.00) | 33.00(10.00–99.00) | 0.461 | 0.861 | 0.336 |
| Day 3 P (ng/mL) | 0.30(0.10–0.80) | 0.30(0.10–0.90) | 0.30(0.10–0.90) | 0.151 | 0.197 | 0.751 |
| Infertility causes, n (%) | ||||||
| Male factor | 193(12.28%) | 215(11.75%) | 309(12.35%) | 0.206 | 0.455 | 0.799 |
| Tubal factor | 736(46.89%) | 825(45.15%) | 1145(45.69%) | |||
| Endometriosis | 18(1.17%) | 36(1.99%) | 39(1.56%) | |||
| Mixed | 577(36.80%) | 685(37.48%) | 942(37.61%) | |||
| Unexplained | 45(2.86%) | 66(3.63%) | 70(2.79%) | |||
| Fertilization method | ||||||
| IVF (%) | 1007(64.18%) | 1104(60.43%) | 1487(59.36%) | 0.077 | 0.183 | 0.023 |
| ICSI (%) | 377(24.03%) | 480(26.27%) | 715(28.54%) | |||
| Half IVF +half ICSI (%) | 185(11.79%) | 243(13.30%) | 303(12.10%) | |||
| Year of treatment (%) | ||||||
| 2007–2010 | 50(3.19%) | 76(4.16%) | 72(2.87%) | <0.001 | <0.001 | <0.001 |
| 2011–2012 | 228(14.53%) | 247(13.52%) | 290(11.58%) | |||
| 2013–2014 | 645(41.11%) | 1044(57.14%) | 918(36.65%) | |||
| 2015–2016 | 646(41.17%) | 460(25.18%) | 1225(48.90%) | |||
Notes: aLetrozole vs HMG; bHMG vs letrozole+HMG; cLetrozole vs letrozole+HMG. Bold values represent statistical significance.