Fig. 1.

Gray matter (GM) volume loss and decrease in white matter (WM) integrity (FA, fractional anisotropy) in DM1 patients. T statistic maps with the results of two sample T test comparing DM1 vs healthy controls (HC) are displayed. Only results surviving multiple comparison adjusting for age and brain size are shown for GM volume. The box plot in Fig. 1a shows the comparison of whole brain GM volume between the DM1 and HC group adjusting for age and head size. Fig. 1b shows areas of greater decrease in DM1 compared with HC. The cortical results were projected on a brain surface and were complemented with subcortical slices; the green boxes and arrows represent the position of these slices in the brain surface. The box plot in Fig. 1c shows the comparison of whole brain WM FA between the DM1 and the HC group adjusting for age. Fig. 1d shows areas of major FA decrease in DM1 vs healthy subjects according to brain region. The bar plots display the T statistics results of the group difference (the magnitude of the difference between the two groups) for all the brain regions.