Table 3.

Gray matter volume loss associated with neuropsychological outcome of DM1 patients.

	Cluster				MNI coordinates
	Size	Mean T	p	Peak ROI Structure	X	Y	Z
IQ estimate	133	3	.005	Left Frontal Pole	−40	40	−8
Arithmetic	181	2.28	.030	Right Cuneal Cortex	4	−84	24
Block design	132	2.66	.013	Left Frontal Pole	−46	44	−8
	257	2.47	.020	Right Precuneus Cortex	10	−64	52
ROCF copy	413	2.65	.013	Left Frontal Orbital Cortex	−20	20	−22
	860	2.64	.013	Left Caudate	−16	−8	20
	180	2.66	.013	Left Precentral Gyrus	−52	6	16
	427	2.62	.014	Left Precentral Gyrus	−52	0	34
	597	2.59	.015	Left Superior Frontal Gyrus	−8	−6	72
ROCF memory	705	2.9	.007	Right Subcallosal Cortex	4	30	−30
	250	2.39	.024	Left Insular Cortex	−30	0	14
	136	2.52	.018	Left Precentral Gyrus	−54	8	38
	116	2.49	.019	Left Inferior Frontal Gyrus	−38	16	26
	328	2.96	.006	Left Precentral Gyrus	−16	−12	76
Object assembly	543	2.47	.020	Right Lingual Gyrus	6	−74	−8
	337	2.67	.012	Right Precentral Gyrus	34	−18	56
	269	2.78	.009	Right Superior Frontal Gyrus	18	−6	68
Stroop Interference	521	2.54	.018	Left Frontal Medial Cortex	−2	32	−28
	197	2.41	.024	Right Putamen	24	8	−6
	232	−2.57	.017	Right Precentral Gyrus	50	4	40
Stroop Word	992	2.63	.015	Left Putamen	−30	6	−8
	872	3.08	.005	Right Caudate	8	16	10
Stroop Color-Word	694	2.61	.015	Left Frontal Orbital Cortex	−18	12	−12
	241	2.52	.019	Right Putamen	24	10	−8
Raven's progressive	147	2.5	.019	Left Inferior Frontal Gyrus	−52	34	−16
matrices	142	2.62	.015	Left Middle Frontal Gyrus	−50	22	32
	390	2.67	.013	Left Precentral Gyrus	−48	−8	46
	251	2.52	.019	Left Superior Parietal Lobule	−40	−40	54
	154	2.58	.016	Left Precuneus Cortex	−10	−54	52
	163	2.74	.011	Right Precuneus Cortex	12	−50	60
Election RT	352	2.58	.017	Left Occipital Pole	−16	−94	0
Sequence 2 RT	469	2.72	.012	Right Frontal Orbital Cortex	10	24	−28
	272	2.37	.026	Left Middle Frontal Gyrus	−46	30	24
	107	2.39	.026	Left Parietal Operculum Cortex	−48	−24	16
	196	2.32	.029	Left Postcentral Gyrus	−44	−16	30

Note. DM1: Myotonic Dystrophy Type 1; MNI: Montreal Neurosciences Institute; ROI: Regions of Interest; IQ: Intelligence Quotient; ROCF: Rey-Osterrieth Complex Figure; RT: Reaction Time. Only results surviving multiple comparisons are shown, correcting for age and head size. The results were then masked to display only those results in the regions where DM1 patients showed a significant decrease in volume compared with healthy controls. For each neuropsychological measure the table shows the cluster size representing the total number of voxels that comprise the cluster; the mean T represents the magnitude of the association between the mean grey matter measure in the cluster and the p-value of this association (Higher T indicates a stronger association).