Table 2.
Intermolecular bonding residues with lamellarin analogues. Chemical groups are shown to chelate with catalytic magnesium ion.
| Compound | H-bond residues | Hydrophobic interaction residues | Mg2+ chelation |
|---|---|---|---|
| 1 | Asp64, Cys65, His67, Glu92 | Asp64, Cys65, Asp116, His67, Glu92, guanine base | - |
| 2 | Glu92 | Cys65, His67, Val72, Glu92, Tyr143, guanine base | - |
| 3 | Glu92 | Cys65, His67, Asp116, Glu92, Tyr143, guanine base | - |
| 4 | Asp64, His67, Glu92, Asp116, guanine base | Asp64, His67, Glu92, Asp116, guanine base | 8-OH |
| 5 | Guanine base | Asp64, Cys65, His67, Glu92, Asp116, Phe121, guanine base | - |
| 6 | Guanine base | Asp64, Cys65, His67, Glu92, Asp116, Phe121, guanine base | 8-OMe |
| 7 | Glu92 | Asp64, Cys65, His67, Glu92, Asp116, Gly118, Pro142, Tyr143, guanine base | 9-OMe |
| 8 | Glu92 | Asp64, Cys65, His67, Val72, Glu92, guanine base | - |