Value of the Data •These data, alongside with those reported in the related research article, show that the application of the ECS protocol guarantees early coagulation support in major trauma patients with high bleeding risk. •Basing on these data, ECS protocol may be adopted by clinicians in real-life management of major trauma patients. •These data can be used to design further prospective studies with the aim to standardize timing and dosing of fibrinogen in the application of ECS protocol in major trauma patients. •The present data give more strength to the results of the related research article confirming a reduction in the average blood product consumption associated with the application of ECS protocol.