Table 10.
Enrichment of KEGG pathways by the genes differentially expressed after 1 day or 5 days (analyses “1d” vs “5d”). Significantly enriched pathways (FDR < 0.05), identified by their KEGG identifier, are grouped according to 7 functionally related groups obtained by ClueGO analysis.
| KEGG Identifier | KEGG ID FDR | Group FDR | Enrichment Score | Groups | % Associated Genes | Nr. Genes | Time | %Genes Specific for 1d | %Genes Specific for 5d |
|---|---|---|---|---|---|---|---|---|---|
| p53 signaling pathway | 11.0E-3 | 11.0E-3 | 6.5 | 5 | 6.76 | 5.00 | Both times | 53.89 | 53.89 |
| Steroid biosynthesis | 210.0E-9 | 210.0E-9 | 22.2 | 0 | 33.33 | 7.00 | Specific for 1d | 100.00 | 0.00 |
| ECM-receptor interaction | 1.3E-3 | 1.3E-3 | 9.6 | 6 | 8.64 | 7.00 | Specific for 1d | 66.84 | 40.11 |
| Alanine, aspartate and glutamate metabolism | 7.6E-3 | 7.6E-3 | 7.0 | 1 | 10.00 | 4.00 | Specific for 1d | 64.60 | 43.07 |
| DNA replication | 8.4E-3 | 8.4E-3 | 6.9 | 3 | 10.53 | 4.00 | Specific for 5 d | 25.00 | 75.00 |
| Arachidonic acid metabolism | 12.0E-3 | 12.0E-3 | 6.4 | 2 | 7.84 | 4.00 | Specific for 5 d | 25.00 | 75.00 |
| Proteasome | 14.0E-3 | 14.0E-3 | 6.2 | 4 | 7.14 | 4.00 | Specific for 5 d | 21.53 | 86.14 |